E-Cadherin and Angiopoietin-2 as Potential Biomarkers for Colorectal Cancer With Peritoneal Carcinomatosis

Background/Aim: E-Cadherin has been implicated in cell-cell adhesion, and soluble E-cadherin is involved angiogenesis resistance to anti-angiogenic therapy several cancer types. This study aimed investigate the expression clinical significance of other angiogenesis-related factors plasma malignant ascites colorectal (CRC) patients with peritoneal carcinomatosis (PC). Materials Methods: Multiplex enzyme-linked immunosorbent assay was performed on 95 body fluid samples (57 38 ascites) from CRC. The status angiopoietin-2 (AGNPT2) retrospectively evaluated by immunohistochemistry primary CRC paired metastatic tissues or cell blocks 30 metastases Results: levels ANGPT2 were significantly increased PC compared those without. concentration lower higher than samples. Expression strongly positive, whilst that negative tissues, immunohistochemistry. High negatively associated overall survival ascites. Conclusion: Our findings suggest may be surrogate biomarkers for outcome